Polar Quassinoids in StandardizedEurycoma longifoliaExtract Formulated into a Lipid-Based Solid Dispersion to Improve Rat Sperm Count
| Autor: | Kit-Lam Chan, Hai-Qiu Ma, Forough Ebrahimi, Nurzalina Abdul Karim Khan, Bin-Seng Low |
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| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
biology Chemistry Area under the curve biology.organism_classification Southeast asian 030226 pharmacology & pharmacy 01 natural sciences Sperm 0104 chemical sciences Bioavailability 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine Quassinoid Eurycoma longifolia Efflux Drug metabolism |
| Zdroj: | Phytotherapy Research. 31:1875-1882 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.5930 |
| Popis: | Eurycoma longifolia Jack is popularly sought in Southeast Asian countries for traditional remedies to improve sexual performance and fertility. 13α(21)-Epoxyeurycomanone and eurycomanone, two major quassinoids in a root extract (TAF2) were reported to improve rat spermatogenesis and fertility. Unfortunately, these quassinoids possess low bioavailability because of high aqueous solubility and low lipid membrane permeability. Often, other possible barriers may be P-glycoprotein (P-gp) efflux in the gut and presystemic hepatic metabolism. The present study attempted to solve these problems by formulating a lipid-based solid dispersion (TAF2-SD) of optimized mixture of TAF2 and emulsifiers, which was then orally administered to rats prior to sperm count analysis. The TAF2-SD-treated rats showed significantly twofold (p |
| Databáze: | OpenAIRE |
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