Sch 53823 and Sch 53825, novel fungal metabolites with phospholipase D inhibitory activity
| Autor: | Mohindar S. Puar, Min Chu, Pradip R. Das, Jin-Keon Pai, Mahesh Patel |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chemistry
Phospholipase D Stereochemistry organic chemicals Organic Chemistry Clinical Biochemistry Pharmaceutical Science DEPT Inhibitory postsynaptic potential Biochemistry carbohydrates (lipids) nervous system Acetylation Drug Discovery polycyclic compounds Molecular Medicine heterocyclic compounds Molecular Biology IC50 Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:579-584 |
| ISSN: | 0960-894X |
| Popis: | Two novel phospholipase D (PLD) inhibitors, Sch 53823 (1) and Sch 53825 (2), were isolated from a fungal culture. The acetylated derivatives, Sch 53827 (3) and Sch 53829 (4), were prepared for the purpose of structure determination. The extensive NMR studies of 3 and 4 including DEPT, COSY, NOESY, HETCOR, and selective INEPT experiments permitted the establishment of their structures, as well as relative stereochemistries. Among these compounds, 3 exhibited the most potent inhibitory activity in the phospholipase D assay with the IC50 = 17 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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