Pregnancy Morbidity Associated with Hereditary and Acquired Thrombophilias: Late Obstetric Complications
| Autor: | Sukrutha Veerareddy, Donald Peebles |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pregnancy
medicine.medical_specialty Placental abruption business.industry Obstetrics Intrauterine growth restriction medicine.disease Thrombophilia law.invention Randomized controlled trial law Antithrombotic Recurrent miscarriage medicine business Adverse effect reproductive and urinary physiology |
| Zdroj: | Disorders of Thrombosis and Hemostasis in Pregnancy ISBN: 9781447144106 |
| DOI: | 10.1007/978-1-4471-4411-3_6 |
| Popis: | As well as being associated with recurrent miscarriage (RM), antiphospholipid antibodies (aPL) are associated with late placental vascular-mediated pregnancy complications such as severe pre-eclampsia, intrauterine growth restriction (IUGR), abruptio placentae, late fetal loss, and stillbirth. There are also associations between heritable thrombophilias and these late pregnancy complications. Finally, venous thromboembolism (VTE) in pregnancy, as in the non-pregnant state, is linked to thrombophilia. In this review, potential adverse effects of thrombophilia in late pregnancy are discussed. Preliminary data suggest that maternal antithrombotic prophylaxis may result in improved pregnancy outcome in selected cases. Randomized trials are needed to evaluate treatment strategies. |
| Databáze: | OpenAIRE |
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