Fragliche Evidenz für den Einsatz des Cholinesterasehemmers Donepezil bei Alzheimer-Demenz - eine systematische Übersichtsarbeit

Autor:	Hanna Kaduszkiewicz, Hans-Peter Beck-Bornholdt, H. van den Bussche, Thomas Zimmermann
Rok vydání:	2004
Předmět:	Research design medicine.medical_specialty business.industry MEDLINE Alternative medicine Disease Placebo medicine.disease Psychiatry and Mental health Neurology mental disorders medicine Dementia Clinical significance Neurology (clinical) business Donepezil Intensive care medicine medicine.drug
Zdroj:	Fortschritte der Neurologie · Psychiatrie. 72:557-563
ISSN:	1439-3522 0720-4299
Popis:	Objective Objective of this systematic review is to determine the level of scientific evidence for the use of Donepezil in Alzheimer's Disease. Methods Ten randomised controlled double-blind trials testing Donepezil versus Placebo were identified in MEDLINE and EMBASE. All ten trials were included in this systematic review. Following a detailed catalogue of criteria the methodological standard of the ten trials was assessed. Results The authors of eight trials postulated statistically significant differences in favour of Donepezil. Unfortunately, the methodological standard of all studies was insufficient. The methodological shortcomings are discussed in detail. Conclusion With regard to severe methodological deficiencies the evidence for the use of Donepezil in moderate to severe Alzheimer's Disease is lacking. But even if the trials had been conducted in a methodologically correct way the clinical relevance of the postulated positive results would have to be questioned.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd93b9583b3fb090d6a1b53afa53393c https://doi.org/10.1055/s-2004-830077 Zobrazit plný text záznamu