Clinical Resistance to Antimetabolites
| Autor: | C. P. Spears |
|---|---|
| Rok vydání: | 1995 |
| Předmět: | |
| Zdroj: | Hematology/Oncology Clinics of North America. 9:397-414 |
| ISSN: | 0889-8588 |
| DOI: | 10.1016/s0889-8588(18)30101-1 |
| Popis: | This article discusses clinically approved and available antimetabolites along with the clinical example of fluorouracil. The thymidylate synthase mechanism of cytotoxicity and results of clinical tumor pharmacodynamics are examined. Some investigational antimetabolites and modulators of fluoropyrimidines, including biological response modifiers, are discussed, as are pharmacokinetic and pharmacogenetic considerations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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