Clinical Effects of Trapidil on Angina Pectoris with Special

Autor:	Yasushi Mizuno, Hiroaki Teshigawara, Keiji Tachi, Hitoshi Hishida, Takeshi Kondo, Masatoshi Wada, Yutaka Miyagi, Susumu Ohashi, Masanori Nomura, Kaneko K, Satoshi Okajima
Rok vydání:	1981
Předmět:	Pharmacology medicine.medical_specialty business.industry Mean value Pressure Rate Treadmill exercise Trapidil medicine.disease Angina Male patient Internal medicine medicine Cardiology Arterial blood Pharmacology (medical) business Beneficial effects medicine.drug
Zdroj:	Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 12:61-71
ISSN:	1882-8272 0388-1601
DOI:	10.3999/jscpt.12.61
Popis:	This study was carried out to investigate effects of trapidil on subjective symptoms, electrocardiograms and, especially, exercise tolerance of patients with angina pectoris. The material consisted of 8 male patients with angina of effort, aged from 46 to 73 years. Trapidil was administered in a dose of 100 mg, 3 times, namely, after each meal, daily for 2 to 13 weeks. The multistage treadmill exercise tests based on modified Bruce's protocol was performed before and after trapidil. The end-point of exercise was anginal pain. Beneficial effects on anginal attack, exercise-induced ST-T changes and exercise tolerance were obtained in 75.0%, 71.4% and 28.6% of the material, respectively. The duration of exercise after trapidil (mean value: 5.21 min.) was significantly (P
Databáze:	OpenAIRE
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