Immuno-allertypes in non-cystic fibrosis bronchiectasis
| Autor: | Veonice Bijin Au, John E. Connolly, Zi Yang Lee, Tidi Hassan, Christopher Martinus, Louis Yuen Sung Tiong, Gan Liang Tan, Thun How Ong, Damien Marlier, Tan Ching Ong, John Abisheganaden, Fook Tim Chew, Albert Yick Hou Lim, Sanjay H. Chotirmall, Kang Ning Wong, Teck Boon Low, Pei Yee Tiew, Sriram Narayanan, Yang Yie Sio, James D. Chalmers, De Yun Wang, Anusha Matta, Holly R. Keir, Sze Lei Pang, Xiao Wei Gwee, Mariko Siyue Koh, Micheál Mac Aogáin |
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| Rok vydání: | 2018 |
| Předmět: |
House dust mite
Allergy Bronchiectasis biology business.industry Disease Immunoglobulin E biology.organism_classification medicine.disease Aspergillus fumigatus 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Immunology Eosinophilic biology.protein medicine 030212 general & internal medicine business Sensitization |
| Zdroj: | Allergy and immunology. |
| DOI: | 10.1183/13993003.congress-2018.pa1142 |
| Popis: | Introduction: The role of allergy and sensitization in non-CF bronchiectasis remains unexplored. Methods: Patients with radiologically confirmed and stable bronchiectasis were enrolled from three different countries (N=238): Singapore and Malaysia (N=138) and Dundee, United Kingdom (N=100). Systemic immune and airway inflammatory profiles were determined including 41cytokines and specific IgE titres against common allergens including; house dust mite (HDM) and the fungi Alternaria alternata and Aspergillus fumigatus. Results: High frequencies of sensitization were observed in stable non-CF bronchiectasis that demonstrate geographic variation. Two distinct clinically relevant clusters (coined “immuno-allertypes”) were identified: a “fungal-driven pro-inflammatory” group characterized by sensitization to fungal allergens and a pro-inflammatory cytokine profile and a “HDM -driven chemokine dominant” group characterized by sensitization to house dust mites and enriched for chemotactic mediators and eosinophilic driven airway inflammation. The “fungal-driven” immuno-allertype associates with more severe disease (p ≤ 0.01) and poorer lung function (p ≤ 0.05) compared to the “HDM driven” group. Conclusion: Two distinct and clinically relevant immuno-allertypes of non-CF bronchiectasis were identified representing a potential ‘treatable trait’ for a disease where limited treatment options currently exist Funding: This research is supported by the Singapore Ministry of Health’s National Medical Research Council under its Transition Award (NMRC/TA/0048/2016) (S.H.C) and the Changi General Hospital Research Grant (CHF2016.03-P) (T.B.L). |
| Databáze: | OpenAIRE |
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