Interaction of enterohemorrhagic Escherichia coli O157:H7 with mouse intestinal mucosa

Autor:	Roberto M. La Ragione, Gad Frankel, W. A. Cooley, Alexandra H A Dugdale, Alan D. Phillips, Francis Girard, Martin J. Woodward, Ute Weyer
Rok vydání:	2008
Předmět:	biology Effector Signal transducing adaptor protein Ileum medicine.disease_cause biology.organism_classification Microbiology Enterobacteriaceae Epithelium Type three secretion system medicine.anatomical_structure Intestinal mucosa Genetics medicine Molecular Biology Escherichia coli
Zdroj:	FEMS Microbiology Letters. 283:196-202
ISSN:	1574-6968 0378-1097
Popis:	In this study, we used mouse ileal loops to investigate the interaction of enterohemorrhagic Escherichia coli (EHEC) O157:H7 with the mouse intestinal mucosa. With a dose of 10(9) and 3 h incubation, EHEC O157 was detected in the lumen and to a lesser extent associated with the epithelium. Typical attaching and effacing (A/E) lesions were seen, albeit infrequently. While the effector protein Tir was essential for A/E lesion formation, the bacterial type III secretion system adaptor protein TccP was dispensable. These results suggest that A/E lesions on mouse intestinal mucosa can be formed independently of robust actin polymerization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd748b4103bae4c08a273d6e76f31298 https://doi.org/10.1111/j.1574-6968.2008.01166.x Zobrazit plný text záznamu Plný text