Synthesis of α-aminoacids by catalytic palladium (O) alkylation of schiff bases

Autor:	J.P. Genet, D. Ferroud, R. Kiolle
Rok vydání:	1986
Předmět:	Hydrolysis Allylic rearrangement Chemistry Organic Chemistry Drug Discovery Glycine Organic chemistry chemistry.chemical_element Alkylation Biochemistry Catalysis Palladium
Zdroj:	Tetrahedron Letters. 27:23-26
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)83929-5
Popis:	Schiff bases 1 b , 1 c , 2 derived from glycine ester or aminoacenotrile were alkylated with allylic acetates 3 a , 3 b or allylic carbonates 3 c , 3 d , 4 a , 4 b (under neutral conditions) in the presence of catalytic amount of palladiun (O). After hydrolysis higher and functionalized α-aminoesters were obtained in good yields (50 to 85 %).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd6fe7cb8eaaf4be28fa1512d98406d4 https://doi.org/10.1016/s0040-4039(00)83929-5 Zobrazit plný text záznamu