Directing Bromination of Piperazine-2,5-diones

Autor:	Christopher J. Easton, Jason B. Harper, D. M. Page, Christina L. L. Chai, T. W. Badran
Rok vydání:	1995
Předmět:	Green chemistry Piperazine chemistry.chemical_compound Reaction mechanism Chemistry Biocatalysis Intramolecular force Substituent Supramolecular chemistry Halogenation General Chemistry Medicinal chemistry
Zdroj:	Australian Journal of Chemistry. 48:1379
ISSN:	0004-9425
DOI:	10.1071/ch9951379
Popis:	From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd6b61f0ea8faffd3ceb56ad55871523 https://doi.org/10.1071/ch9951379 Zobrazit plný text záznamu