Biologically active heparin-like fragments with a 'non-glycosamino'glycan structure. Part 2 : a tetra-o-methylated pentasaccharide with high affinity for antithrombin III
| Autor: | B. Olde-Hanter, M. Petitou, Jan E. M. Basten, C.A.A. van Boekel, G. Jauran |
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| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
Glycan biology Stereochemistry Heparin like Organic Chemistry Clinical Biochemistry Antithrombin Disaccharide Pharmaceutical Science Biological activity Oligosaccharide biology.organism_classification Biochemistry Glycosaminoglycan chemistry.chemical_compound chemistry Drug Discovery biology.protein medicine Molecular Medicine Tetra Molecular Biology medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 2:901-904 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80584-3 |
| Popis: | To simplify the preparation of biologically active oligosaccharide analogues of glycosaminoglycan fragments we describe an approach where N-sulphates are replaced by O-sulphates and free hydroxyls are substituted by methyl groups. In this communication we report on the synthesis of a pentasaccharide in which hydroxyl groups of the non-reducing end disaccharide sub-region are methylated. The biological properties of this chemically modified analogue are fully preserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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