Weight Loss Post Allogeneic Stem Cell Transplant is Associated with Increased Transplant Related Mortality

Autor: Kayla Madsen, Katherine Lee, Shiyi Chen, Carol Chen, Arjun Law, Armin Gerbitz, Rajat Kumar, Dennis Kim, Wilson Lam, Ivan Pasic, Auro Viswabandya, Fotios Michelis, Ram Vasudevan Nampoothiri, Jeffrey Lipton, Igor Novitzky-Basso, Jonas Mattsson
Rok vydání: 2022
Popis: Purpose: Allogeneic Stem Cell Transplant (allo-HSCT) patients are at risk of malnutrition and weight loss from impaired oral intake resulting from gastrointestinal toxicities, dysgeusia, and psychological effects. Methods: A retrospective review of 264 adult patients transplanted at Princess Margaret Cancer Centre who achieved relapse-free survival up to 3 months after allo-HSCT was performed. Results: Overall incidence of patients who experienced WL (WL) ≥10% from HSCT to 3 months post-transplant was 45.9% and from HSCT to 6 months was 56.6%. Patients with ≥10% WL from allo-HSCT at 3-months and 6 months had similar 2-year overall survival (OS) compared to those with Conclusion: Approaches to WL post allo-HSCT should be multifaceted and include members of the interdisciplinary team in order to decrease TRM.
Databáze: OpenAIRE