Usefulness of 99Tcm-N,N′-ethylene-l-dicysteine complex for dynamic kidney investigations
| Autor: | M. J. Surma, J. Liniecki, J. Wiewióra |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Kidney
medicine.diagnostic_test business.industry Chemistry Iodohippuric Acid Renal function General Medicine Effective renal plasma flow Scintigraphy Excretion Nuclear magnetic resonance medicine.anatomical_structure Pharmacokinetics medicine Radiology Nuclear Medicine and imaging Nuclear medicine business Technetium-99m |
| Zdroj: | Nuclear Medicine Communications. 15:628-635 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199408000-00007 |
| Popis: | To assess the usefulness of the 99Tcm-N,N'-ethylene-1-dicysteine (99Tcm-EC) complex for examination of kidney function, dynamic kidney scintigraphy with 99Tcm-EC and clearance determinations were performed. During renoscintigraphy the kidney images were of superb quality, with overlying organs (liver, spleen) not visualized. Renograms showed typical shapes, their Tmax and T1/2 values being unsignificantly different from the values obtained with other radiopharmaceuticals used in renoscintigraphy (mercaptoacetyl triglycine, hippuran). Very strict correlations were found between values of 99Tcm-EC and 131I-iodohippurate (OIH) clearances (r = 0.91) and excretion rate constants (r = 0.92) for both radiopharmaceuticals. The correlation enabled the formulation of an equation by which effective renal plasma flow (ERPF) could be established from 99Tcm-EC clearance: ERPFOIH = 1.245 x ClEC + 51.52. On the basis of this equation a lower boundary of the normal 99Tcm-EC clearance was established; it amounts to 300 ml min-1 1.73 m-2. |
| Databáze: | OpenAIRE |
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