Study on VDR Polymorphism Influence in Associating with Diabetes Mellitus

Autor:	D. Cimponeriu, Lavinia Mariana Berca, Claudia-Elena Mosoiu, P. Apostol, Silvia Nica, Remus Nica
Rok vydání:	2021
Předmět:	medicine.medical_specialty endocrine system diseases business.industry medicine.disease Applied Microbiology and Biotechnology Calcitriol receptor Endocrinology Internal medicine Diabetes mellitus Genetics medicine business Agronomy and Crop Science Biotechnology
Zdroj:	Romanian Biotechnological Letters. 26:2249-2254
ISSN:	2248-3942 1224-5984
DOI:	10.25083/rbl/26.1/2249.2254
Popis:	The aim of this study was to evaluate the association between vitamin D receptor, IL6 polymorphisms and DM. DNA was used to genotype the VDR FokI (rs2228570), TaqI (rs731236) and ApaI (rs7975232) polymorphisms by PCR RFLP and IL6 G-174C (rs1800795) by tetra-primer ARMS PCR. The presence of torque teno viruses DNA was assessed with heminested-PCR. For this study T1DM (n = 107) and T2DM (n = 124) patients and matched clinically healthy subjects (n = 200) were recruited. T1DM patients have a tendency to be more frequent carriers of the C allele and TTV infection than controls (OR = 1.9, p = 0.03). VDR tt genotype and VDR “FAt” haplotype are risk factors for T1DM. VDR “fAt” haplotype may increases the risk for T2DM. These associations were not changed after exclusion from statistical analysis of patients with hypertension, myocardial infarction, stroke or breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd5ece8631def63eb3a874454208a43c https://doi.org/10.25083/rbl/26.1/2249.2254 Zobrazit plný text záznamu