A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo
| Autor: | Yumin Wang, Ying Zhou, Jun Feng Zhang, Junwei Xiong, Lina Huang, Yu Chen, Xianghua Wu, Yu-Qiang Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indole test
biology Chemistry Near-infrared spectroscopy 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Fluorescence 0104 chemical sciences HeLa In vivo Biophysics Sensitivity (control systems) 0210 nano-technology Selectivity Rapid response |
| Zdroj: | Chinese Chemical Letters. 31:2941-2944 |
| ISSN: | 1001-8417 |
| Popis: | Iron is one of the essential trace elements in the human body. It plays an important role in human biology and pathology. Deregulation of iron levels in cells is associated with disease development. In this work, we synthesized a novel near-infrared intramolecular charge transfer (ICT) based ratiometric fluorescent probe to detect Fe2+, by using naphthalimide and indole moieties as building blocks. Our work showed that the radiometric probe has excellent selectivity, sensitivity and rapid response. Moreover, we could successfully perform real-time monitoring of Fe2+ in HeLa cells and C. elegans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect