| Autor: |
R. Carpignano, Michele Trotta, Maria Rosa Gasco, Maria Eugenia Carlotti |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 18:235-245 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(84)90139-x |
| Popis: |
The influence of 3 series of acids (monocarboxylic and bicarboxylic aliphatic, and monosubstituted aromatic) on the permeability of imipramine through a dimethyl-polysiloxane membrane was determined. All the series of acids give an increase of the permeability as a consequence of an ion-pair formation. Hansch and Free-Wilson statistical approaches were applied to correlate permeability constants with physicochemical and structural parameter, respectively, of the acids. Hansch analysis shows the importance of hydrophobic factors. Free-Wilson analysis allows to calculate the contributions of structural features to the ion-pair permeability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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