| Popis: |
Diphenylhydantoin was administered orally to young guinea pigs for 99 days in an average daily dose by body weight approximately 10 times that recommended for human adults with convulsive disorders. Control guinea pigs on an identical diet without diphenylhydantoin were pair-fed with the above to counteract the effect of the drug on appetite. Standardized dermal wounds were inflicted, and porous polyvinyl sponges were implanted subcutaneously to study wound healing in the two groups. There was no difference in healing rate as judged by our testing procedure, which evaluates each animal's local reaction to wounding by physical, histopathologic, and biochemical methods. Complete necropsies including microscopic examination showed no consistent lymph node changes that could be attributed to diphenylhydantoin. Because of previous reports in man of lymphadenopathy, pseudolymphoma, and true lymphoma, special attention was paid to lymph nodes, spleen, bone marrow, and liver. In approximately one-third of the treated group amorphous splenic deposits were found with a positive staining reaction for amyloid. |
