Radiosynthesis of tritium-labeled novel nitromethylene neonicotinoids compounds with NaB3H4

Autor:	Ju-Ying Li, Zhong Li, Chao Li, Xiaoyong Xu, Qingfu Ye
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Organic Chemistry Radiosynthesis Nitro compound Neonicotinoid Cycloxaprid Biochemistry Chemical synthesis Analytical Chemistry chemistry Drug Discovery High activity Organic chemistry Radiology Nuclear Medicine and imaging Tritium Paichongding Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 54:256-259
ISSN:	0362-4803
Popis:	Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid-resistant pest. In this paper, the radiosynthesis of [3H2]-Paichongding and [3H2]-Cycloxaprid was achieved using a NaB3H4 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology. Copyright © 2011 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd4617d4aaf9369c336cccb7816e35bd https://doi.org/10.1002/jlcr.1862 Zobrazit plný text záznamu Plný text