No impact of DvSnf7 RNA on honey bee (Apis mellifera L.) adults and larvae in dietary feeding tests
| Autor: | Geoffrey M. Mueller, Michael H. Beevers, Zihong Song, Chen Meng, Peter D. Jensen, Kathy B. Richards, Steven L. Levine, Jianguo Tan, Joshua P. Uffman, Pamela M. Bachman |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Pollination biology business.industry Health Toxicology and Mutagenesis fungi food and beverages Zoology Genetically modified crops Honey bee Environmental exposure Pesticide biology.organism_classification medicine.disease_cause Biotechnology 03 medical and health sciences 030104 developmental biology Western corn rootworm Pollinator Pollen medicine Environmental Chemistry business |
| Zdroj: | Environmental Toxicology and Chemistry. 35:287-294 |
| ISSN: | 0730-7268 |
| Popis: | The honey bee (Apis mellifera L.) is the most important managed pollinator species worldwide and plays a critical role in the pollination of a diverse range of economically important crops. This species is important to agriculture and historically has been used as a surrogate species for pollinators to evaluate the potential adverse effects for conventional, biological, and microbial pesticides, as well as for genetically engineered plants that produce pesticidal products. As part of the ecological risk assessment of MON 87411 maize, which expresses a double-stranded RNA targeting the Snf7 ortholog (DvSnf7) in western corn rootworm (Diabrotica virgifera virgifera), dietary feeding studies with honey bee larvae and adults were conducted. Based on the mode of action of the DvSnf7 RNA in western corn rootworm, the present studies were designed to be of sufficient duration to evaluate the potential for adverse effects on larval survival and development through emergence and adult survival to a significant portion of the adult stage. Testing was conducted at concentrations of DvSnf7 RNA that greatly exceeded environmentally relevant exposure levels based on expression levels in maize pollen. No adverse effects were observed in either larval or adult honey bees at these high exposure levels, providing a large margin of safety between environmental exposure levels and no-observed-adverse-effect levels. |
| Databáze: | OpenAIRE |
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