| Popis: |
A novel HLA-DPB1 allele (DPB1 ∗ WA6) has been identified in West Africa, and the occurrence of the recently reported allele DPB1 ∗ 4001 (DPB1 ∗ BRI-5) in Negroid populations has been confirmed DPB1 ∗ WA6 differs from DPB1 ∗ 0101 by a silent nucleotide exchange at codon position 43 only. It constitutes, thereby, a link to DPB1 ∗ 1101, ∗ 1501, and ∗ 2601 and suggest an evolutionary relationship with these alleles. Carrying the same silent mutation, DPB1 ∗ 1101, ∗ 1501, and ∗ 2601 may, by recombinations, have evolved from DPB1 ∗ WA6. An apparently older evolutionary branch arose directly from DPB1 ∗ 0101 and comprises the closely related alleles DPB1 ∗ 2701 and DPB1 ∗ 4001 reported only from individuals of African descent. |
