Low-dose nuclear microscopy as a necessity for accurate quantitative microanalysis of biological samples

Autor:	M. Maetz, Wojtek J Przybylowicz, K. Traxel, Arthur Schüßler, Jolanda Mesjasz-Przybylowicz
Rok vydání:	1999
Předmět:	Matrix (chemical analysis) Nuclear and High Energy Physics Trace Amounts Chemistry Sample (material) Nondestructive analysis Low dose Analytical chemistry Instrumentation Quantitative analysis (chemistry) Microanalysis Nuclear microscopy
Zdroj:	Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 158:292-298
ISSN:	0168-583X
DOI:	10.1016/s0168-583x(99)00331-6
Popis:	Some aspects of quantitative analysis of biological samples – including a review of the relevant literature – are discussed. Special emphasis is put on the accuracy of trace elemental results despite severe sample damage which occurs during analysis. The occuring mass loss can be corrected by combining quantitative STIM and PIXE. It is also possible to characterize the volatility of most of the minor and trace elements of the sample. The comparison between the presented model and matrix determination with RBS, a widely used method, definitely demonstrates that the concentrations obtained using RBS correction only may be too high by a factor of two. We recommend at least one low-dose analysis to do correct quantification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd2d3012c594e38010c68d511f8bcd5d https://doi.org/10.1016/s0168-583x(99)00331-6 Zobrazit plný text záznamu Full Text from ScienceDirect