| Popis: |
The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; V is sulpur or carbon; R 3 is oxygen or fluorine; R 4 is an optionally present C 1-3 alkyl group optionally substituted by fluorine; R 5 is an optionally present cyclic group with 5-7 heavy atoms in the ring which may be carbocyclic or heterocyclic and aromatic or aliphatic and is optionally substituted, e.g. by a halogen, C 1-2 alkyl or fluoroalkyl, OH, OR 6 , cyano, COOR 6 , CONHR 6 , sulfonamide or NHR 6 , in which R 6 is a C 1-2 alkyl or fluoroalkyl; at least one of R 4 and R 5 is present and R 4 and R 5 may both be present; m and n are each 1 or 2 depending on the identity of V and R 3 ; when n=2 each R 3 may be the same or different but are preferably the same, when m=2, each R 4 and each R 5 may be the same or different but are preferably the same; and W represents hydrogen, carbon, nitrogen, oxygen or sulphur; or incorporating a salt, hydrate or solvate of a group of formula (I); as well as therapeutic uses of these compounds, in particular as inhibitors of protein kinase activity and in the treatment of inflammation, inflammatory conditions and cancer. |
