Treatment of Meningeal Leukemia With Pyrimethamine
| Autor: | George F. Geils, Charles M. Baugh, Charles E. Butterworth, Charlie W. Scott |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Myeloid
Acute myeloblastic leukemia business.industry Immunology Meninges Cell Biology Hematology Pharmacology medicine.disease Biochemistry Leukemia medicine.anatomical_structure Pyrimethamine hemic and lymphatic diseases Toxicity medicine Distribution (pharmacology) business Meningeal Leukemia medicine.drug |
| Zdroj: | Blood. 38:131-137 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v38.2.131.131 |
| Popis: | Pyrimethamine, a substituted pyrimidine with potent folate antagonistic properties, was given orally to treat two episodes of meningeal leukemia in a longterm survivor with acute myeloblastic leukemia. Remissions of seven and at least 6 mo duration were obtained on the two occasions. Spinal fluid concentrations of pyrimethamine were 10-25% of the simultaneous plasma concentrations. Considerations regarding lipid solubility, body distribution, and easily reversible toxicity of pyrimethamine suggest that further therapeutic trials are warranted, especially in childhood lymphoblastic leukemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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