| Popis: |
Background The aetiology of Parkinson's disease (PD) is indistinct, but previous studies of different ethnicities have shown that genetic variations in synuclein alpha (SNCA) have an essential character in the risk of PD. The relation between SNCA intronic single nucleotide polymorphisms (SNPs) and the risk of PD is unclear. Based on the general population and five ethnic groups, this article managed a meta-analysis about the connection of SNCA intronic SNPs with the PD genetic predisposition. Methods This study was implemented according to the 24-step guideline, with strict criteria. The analysis was performed using Stata 16.0 software. Five genetic models were used to analyze the strength of the association, which was quantified by OR value and 95% CI. Results We included 15433 cases and 34143 controls from 31 articles. 6 SNPs in the intron region were screened, and 5 SNPs were statistically significant. Three variants augmented the PD susceptibility (rs2736990, rs3822086, and rs3857059), and two SNPs decreased the risk (rs356186 and rs7684318). Subgroup analysis showed that rs2736990 and rs3822086 carriers added the PD genetic predisposition in the East Asian group. European and Latin group carrying rs3857059 and rs2736990 is the high-risk populations of PD. Conclusions This study finally found 5 SNCA intronic SNPs related to the risk of PD. And racial factors should not be ignored. |
