Asymmetric Suzuki–Miyaura cross-coupling of aryl chlorides with enhancement of reaction time and catalyst turnover

Autor:	Toshinori Kamei, Tetsuo Iwasawa, Akihiro Sato
Rok vydání:	2011
Předmět:	Aryl Organic Chemistry Enantioselective synthesis Biochemistry Medicinal chemistry Chloride Catalysis chemistry.chemical_compound chemistry Yield (chemistry) Phosphonite Drug Discovery medicine Organic chemistry Enantiomeric excess Boronic acid medicine.drug
Zdroj:	Tetrahedron Letters. 52:2638-2641
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.03.051
Popis:	A series of new chiral phosphonite ligands were evaluated for the palladium-catalyzed asymmetric Suzuki–Miyaura cross-coupling reactions of aryl chlorides. Ligand 4 gave 91% yield and 78% ee with 0.5 mol % catalyst loading for the coupling of aryl boronic acid and aryl chloride in 5 h. When the catalyst loading was lowered to 0.1 mol % the same reaction gave 75% yield and 76% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd0ebb4c9c9c7a0adba389fbffd56705 https://doi.org/10.1016/j.tetlet.2011.03.051 Zobrazit plný text záznamu Full Text from ScienceDirect