Chemical Constituents of the Leaves of Caloncoba welwitschii Gilg
| Autor: | Alembert T. Tchinda, Denis Zofou, Marguerite Hortence K. Tchuendem, Turibio Kuiate Tabopda, Ewa Cieckiewicz, Michel Frederich, Pascal D. Douanla, Augustin E. Nkengfack |
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| Rok vydání: | 2018 |
| Předmět: |
Strain (chemistry)
biology 010405 organic chemistry Stereochemistry Plasmodium falciparum Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences In vitro model 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Flacourtiaceae Lactate dehydrogenase Chemical constituents Kaempferol Agronomy and Crop Science Caloncoba welwitschii Biotechnology |
| Zdroj: | Phytochemistry Letters. 23:5-8 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2017.10.019 |
| Popis: | Two new compounds namely acetylcaloncobaside (1) and friedocaloncobic acid (2) were isolated from the leaves of Caloncoba welwitschii together with six known compounds. Their structures were determined by standard spectroscopic methods including one- and two-dimensional NMR, EI-MS, and HRESIMS. The new compounds were established as kaempferol 4′,7-dimethoxy-3-O-(3″,4″,6″-O-triacetyl)-β- null -glucopyranoside (1) and 15β-hydroxy-3-oxo-28-friedelanoic acid (2). The isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum, using the semi-automated in vitro model with parasite lactate dehydrogenase assay. |
| Databáze: | OpenAIRE |
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