Novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals

Autor:	Viviane Gomes Bonifácio, Fernando Campanhã Vicentini, Luiz H. Marcolino-Junior, Bruno C. Janegitz, Orlando Fatibello-Filho
Rok vydání:	2016
Předmět:	Chromatography Chemistry Potassium 010401 analytical chemistry Organic Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Ranitidine medicine medicine.drug
Zdroj:	Canadian Journal of Chemistry. 94:604-607
ISSN:	1480-3291 0008-4042
DOI:	10.1139/cjc-2015-0571
Popis:	A novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals is reported. The method is based on a compound formed in a reaction using ranitidine with and potassium permanganate in neutral media, which can be monitored at 430 nm. Under optimal conditions, an analytical curve was constructed, which was linear in the range between 5.0 × 10−5 and 1.0 × 10−3 mol L−1 with a detection limit of 1.0 × 10−5 mol L−1. In addition, the sample throughput was 60 h−1 and the obtained results for commercial formulation samples by applying the proposed method were in good agreement with labeled values and those obtained by a reference method at a 95% confidence level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd07e4d7dcb403bcad34e55bc07e472c https://doi.org/10.1139/cjc-2015-0571 Zobrazit plný text záznamu Plný text ve formátu PDF