Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: Relation to ataxia

Autor:	John E. Desmond, Adolf Pfefferbaum, Edith V. Sullivan, Kelvin O. Lim, Anjali Deshmukh
Rok vydání:	2000
Předmět:	Cerebral atrophy Cerebellum Ataxia Anatomy Grey matter medicine.disease Central nervous system disease White matter Neuropsychology and Physiological Psychology medicine.anatomical_structure Cerebellar hemisphere medicine medicine.symptom Korsakoff's syndrome Psychology Neuroscience
Zdroj:	Neuropsychology. 14:341-352
ISSN:	1931-1559 0894-4105
DOI:	10.1037/0894-4105.14.3.341
Popis:	The authors used magnetic resonance imaging to measure gray and white matter volumes in cerebellar hemispheres and 4 vermian regions in 61 normal control (NC) men aged 23-72 years, 25 men with uncomplicated alcoholism (ALC), and 8 men and 1 woman with alcoholic Korsakoff s syndrome (KS). NC and ALC took quantitative gait and balance tests. Gray but not white matter volume declined with normal age in both hemispheres and anterior-superior vermis. ALC had gray but not white matter cerebellar hemisphere volume deficits, whereas KS had deficits in both tissue types. ALC and KS had gray and white matter volume deficits in anterior superior but not posterior inferior vermis. ALC had a 1 SD ataxia deficit, significantly and selectively correlated with white matter volume in anterior superior vermis. Regional distribution but not severity of cerebellar volume deficits is similar in alcoholic individuals whether or not complicated by KS and relates to ataxia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd06400ff0dde57e0281646681fa2234 https://doi.org/10.1037/0894-4105.14.3.341 Zobrazit plný text záznamu