Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment

Autor:	Keisuke Hashizume, Haruhiko Fuwa, Makoto Sasaki, Koichi Tsubone
Rok vydání:	2011
Předmět:	Antifungal Stereochemistry medicine.drug_class Organic Chemistry Convergent synthesis Total synthesis Ether Ring (chemistry) Biochemistry chemistry.chemical_compound Aldol reaction chemistry Drug Discovery Side chain medicine Stereoselectivity
Zdroj:	Tetrahedron. 67:6600-6615
ISSN:	0040-4020
Popis:	A stereocontrolled synthesis of a fully elaborated GHIJ-ring fragment of gambieric acids, which are potent antifungal polycyclic ether natural products, has been accomplished. The synthesis features convergent assembly of the tetracyclic polyether skeleton through aldol coupling/cyclodehydration/reductive etherification processes and stereoselective construction of the J-ring side chain by a CeCl 3 -promoted Julia–Kocienski olefination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cd04c80ac03209f3c28736f992e59f24 https://doi.org/10.1016/j.tet.2011.05.082 Zobrazit plný text záznamu Full Text from ScienceDirect