| Autor: |
Reza Ghodssi, Deanna L. Kelly, Hadar Ben-Yoav, Eunkyoung Kim, Thomas E. Winkler, G. R. Costa, S. M. Restaino, Gregory F. Payne, Sheryl E. Chocron |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII). |
| DOI: |
10.1109/transducers.2013.6626766 |
| Popis: |
We present the first demonstration of an electrochemically-active biomaterial probe for schizophrenia treatment monitoring, and its integration in lab-on-a-chip devices. The probe consists of the naturally derived polymer, chitosan, grafted with catechol to provide a redox cycling system. These modifications to the probe significantly amplify the electrochemical signal generated by the antipsychotic drug clozapine, improving the signal-to-noise ratio and overall biosensing performance. The amplified signal generated by clozapine using the lab-on-a-chip with catechol-modified chitosan microelectrodes was 2.46-fold higher compared to unmodified microelectrodes. Additionally, human serum was tested to resemble future utilization in point-of-care analysis of schizophrenia patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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