Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists

Autor:	David O. Calligaro, David Lodge, Paul L. Ornstein, Arnold Macklin Brian, Jack B. Deeter, Darryle D. Schoepp, Nancy K. Augenstein, J. David Leander
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Amino acid chemistry.chemical_compound Drug Discovery Molecular Medicine NMDA receptor Epimer Tetrazole Enantiomer Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 3:2067-2072
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)81017-9
Popis:	We report the synthesis and characterization of the enantiomers of some C-6 epimeric tetrazole- and phosphonic acid-substituted decahydroisoquinoline competitive NMDA antagonists. We found that the absolute stereochemistry of the amino acid center was different for the active enantiomers of each C-6 epimer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ccfd935b97077c3de5a7f8df3b52db60 https://doi.org/10.1016/s0960-894x(01)81017-9 Zobrazit plný text záznamu