Elucidating the Complex Phase Behavior of a Cocrystal System Containing Two APIs and One Coformer
| Autor: | Maria Paulene Abundo, Pui Shan Chow, Reginald B. H. Tan, Zai-Qun Yu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
General Chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences Cocrystal Fourier transform spectroscopy 0104 chemical sciences chemistry.chemical_compound Crystallography chemistry Succinic acid Attenuated total reflection Phase (matter) General Materials Science Ternary operation Phase diagram Eutectic system |
| Zdroj: | Crystal Growth & Design. 19:157-165 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | A method has been developed to determine the phase behavior of a cocrystal system that contains two APIs (active pharmaceutical ingredients) and one coformer. Isoniazid, nicotinamide, and succinic acid (denoted as A, B, and C, respectively, hereafter) can form a ternary cocrystal ABC, along with two binary cocrystals, A2C and B2C, making the phase behavior very complex because of a variety of eutectic points. The phase diagram of such a complex system has never been reported. During experiment, solids of A, B, C, or A2C were added in lots to suspensions of pure ABC cocrystal or a mixture of ABC and another solid phase. Attenuated total reflectance Fourier transform spectroscopy (ATR-FTIR) was used to measure the concentrations of A, B, and C during the process. The constitution of solid phases in suspension at each equilibrium point was determined in a real-time manner by performing mass balance between the liquid and solid phase. Multiple eutectic points in equilibrium with a mixture of ABC and A2C, a mi... |
| Databáze: | OpenAIRE |
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