Synthesis of Cross-Linking Chitosan-Hyaluronic Acid Based Hydrogels for Tissue Engineering Applications
| Autor: | Chan-Khon Huynh, Long Vuong-Hoang Nguyen, Toi Vo Van, Thi-Hiep Nguyen, Nghi Thi-Phuong Nguyen, Nam Minh-Phuong Tran |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chemistry technology industry and agriculture Future application macromolecular substances 02 engineering and technology engineering.material 021001 nanoscience & nanotechnology complex mixtures Aldehyde Cartilage tissue engineering carbohydrates (lipids) Chitosan 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Tissue engineering Chemical engineering Hyaluronic acid Self-healing hydrogels engineering Biopolymer 0210 nano-technology |
| Zdroj: | 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) ISBN: 9789811043604 |
| DOI: | 10.1007/978-981-10-4361-1_115 |
| Popis: | In this study, Hyaluronan-Chitosan (HA/Cs) gel was fabricated by hydrogel method. The aim of the research is to modify the structure of HA molecules into Aldehyde Hyaluronic acid (AHA) and associate it with a second modified biopolymer, N,O-Carboxymethyl Chitosan (NOCC) without using a crosslinker to create a biocompatible hydrogel that can be used as a bio glue for many tissue engineering applications, such as: post-operative peritoneal adhesions, cartilage tissue engineering, osteoarthrosis therapy, surgical adhesive, etc. AHA-NOCC hydrogels have been characterized using FTIR spectroscopy to confirm the substitutions of carboxymethyl groups on the amino and hydroxyl sites of NOCC and aldehyde groups in AHA. The hydrogels were expected to meet the requirement of bioglue for future application. |
| Databáze: | OpenAIRE |
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