Hematopoietic stem cells are a critical sub-population of whole bone marrow in the treatment of myocardial infarction

Autor:	Richard C. Allsopp, Livingston Wong, Brienne Walker, Philip Davy
Rok vydání:	2013
Předmět:	Cardiac function curve education.field_of_study business.industry Population CD34 medicine.disease Transplantation Andrology Haematopoiesis Immunology medicine Myocardial infarction Stem cell education business Whole Bone Marrow
Zdroj:	Stem Cell Discovery. :117-126
ISSN:	2161-6787 2161-6760
DOI:	10.4236/scd.2013.32016
Popis:	Recent studies suggest that whole bone marrow (WBM) derived stem cells may facilitate recovery following myocardial infarction. However, the sub-population of WBM responsible for recovery remains uncertain. By adjusting the abundance of CD34+LinNeg cells in human bone marrow we examined the relative significance of hematopoietic stem cells (HSC) in the recovery of cardiac function in a murine model of induced myocardial infarction. Enrichment of HSC by ~100-fold in WBM transplanted into mice significantly increased recovery of heart function and reduced scar size compared to transplantation of WBM depleted in HSC by ~10-fold (P P P P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ccf52388caf922c81002f8bdb9bd34dd https://doi.org/10.4236/scd.2013.32016 Zobrazit plný text záznamu