Stimulation of the Basal Nucleus of Meynert in Senile Dementia of Alzheimer’s Type

Autor:	P.L. McGeer, I.M. Turnbull, B. Pate, L. Beattie, D. Calne
Rok vydání:	1985
Předmět:	medicine.medical_specialty Basal nucleus Stimulation Senile dementia Basal (phylogenetics) medicine.anatomical_structure Endocrinology Cerebral cortex Internal medicine Brain stimulation medicine Surgery Neurology (clinical) Psychology Metabolic activity Neuroscience
Zdroj:	Stereotactic and Functional Neurosurgery. 48:216-221
ISSN:	1423-0372 1011-6125
Popis:	The basal nuclei of Meynert are the principal sources of cholinerigic innervation of the cerebral cortex. It has been hypothesized that the depressed cortical glucose metabolic activity in senile dementia of Alzheimer’s type (SDAT) may result primarily from diminished activity and loss of these cells. The present study was designed to test the hypothesis that electrical stimulation of the basal nuclei would bring about clinical improvement and increase cortical glucose metabolic activity in SDAT. An electrode was implanted in September 1984 into the left basal nucleus of a 74-year-old man with SDAT. Repetitive cycles of stimulation for 9 months since have had no definite effect clinically but a follow-up positron emission tomography scan shows that cortical glucose metabolic activity was preserved in the ipsilateral temporal and parietal lobes while it declined elsewhere in the cortex.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ccf2ce6b863d8f6a85a52c5a83f8f4d4 https://doi.org/10.1159/000101130 Zobrazit plný text záznamu