Comparison of ER, PR, Ki67 and HER-2/neu Reactivity Pattern with Patients’ Age, Histologic Grade, Tumor Size and Lymph Node Status in Invasive Ductal Breast Cancer
| Autor: | Mahsa Ahadi, Sara Zahedifard, Motahareh Heibatollahi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Gastroenterology 03 medical and health sciences 0302 clinical medicine Breast cancer Her 2 neu Internal medicine medicine Neoplasm Pharmacology (medical) Radiology Nuclear Medicine and imaging Lymph node Tumor size business.industry Cancer medicine.disease Invasive ductal breast cancer 030104 developmental biology medicine.anatomical_structure Oncology Hormone receptor 030220 oncology & carcinogenesis Surgery business |
| Zdroj: | International Journal of Cancer Management. 13 |
| ISSN: | 2538-497X 2538-4422 |
| Popis: | Background: Breast cancer is the most prevalent neoplasm diagnosed in Iranian women. Objectives: The current study was performed to measure the hormone receptor status and its possible connection with the patient’s age, tumor size, histological grade, and lymph node status and involvement in patients with invasive ductal breast cancer (IDBC) Methods: A total of 103 women with IDBC recently diagnosed at the Department of Pathology of Shohada-E-Tajrish Hospital were entered into this study. The mean age of the patients was 48.4 years, and 59.2% of cases were 50 years old or less. Results: Most lesions (78.6%) were more than 2 cm at their greatest dimension. Grade-II lesions were observed in a large number of patients and 59.8% of cases had lymph node involvement. Positive ER, PR, and HER-2/neu were detected in 59%, 57%, and 29% of patients, respectively. A significant correlation was found between patients’ age and histologic score, tumor dimension and both histologic score and nuclear grade, and, finally, between lymph node involvement and nuclear grade. Conclusions: According to previous studies, the evaluation of hormone receptor status in patients with breast cancer is strongly recommended. Here, by studying its possible connection with the patient’s age, tumor size, histological grade, and lymph node metastasis, we detected some biomarkers, which could be used as prognostic indices in these patients. These biomarkers could help us in the clinical management of patients with IDBC by providing the best therapeutic options. |
| Databáze: | OpenAIRE |
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