Cognitive Function in an Elderly Population
| Autor: | Anna Vogiatzoglou, Helga Refsum, Harald A. Nygaard, A. D. Smith, Per Magne Ueland, Eha Nurk, Christian A. Drevon, Knut Engedal, Grethe S. Tell, Stein Emil Vollset |
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| Rok vydání: | 2013 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty education.field_of_study Homocysteine business.industry Population Methylmalonic acid medicine.disease Psychiatry and Mental health chemistry.chemical_compound Endocrinology chemistry Diabetes mellitus Internal medicine medicine Vitamin B12 medicine.symptom business education Applied Psychology Depression (differential diagnoses) Cognitive deficit |
| Zdroj: | Psychosomatic Medicine. 75:20-29 |
| ISSN: | 0033-3174 |
| Popis: | Objective To investigate the cross-sectional relation between metabolic markers of vitamin B(12) status and cognitive performance, and possible effect modification by the presence of depression and apolipoprotein E (ApoE) e4. Methods This is a population-based study of 1935 participants, aged 71 to 74 years, from Norway. Participants were administered a cognitive test battery, and vitamin B(12) status was assessed by measurements of plasma vitamin B(12), holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine. Results The geometric mean (95% confidence interval) for vitamin B(12) was 348 pM (341-354), whereas 5.9% of participants had vitamin B(12) levels lower than 200 pM. In linear regression analyses, holoTC (p = .039) and the holoTC/vitamin B(12) ratio (p = .013) were positively related, whereas MMA (p = .010) was inversely related, to global cognition, after adjustment for sex, education, ApoE status, plasma creatinine, and history of diabetes, cardiovascular disease, hypertension, and depression. Among those positive for ApoE e4, but not among those without the e4 allele, plasma vitamin B(12) was positively associated with global cognition (p = .015), whereas MMA was inversely related to global cognition (p = .036) and executive function (p = .014). In participants with depression, MMA was inversely associated with global cognition (p Conclusions Among the well-nourished elderly, low vitamin B(12) status is associated with cognitive deficit, particularly in those with the ApoE e4 allele or with depression. |
| Databáze: | OpenAIRE |
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