Oxytocin receptor dynamics in the brain across development and species
| Autor: | Elizabeth A. D. Hammock, Radhika Vaidyanathan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neuropeptide Biology Oxytocin receptor Life stage Tissue specificity 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Developmental Neuroscience Oxytocin medicine Tissue distribution Receptor Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Developmental Neurobiology. 77:143-157 |
| ISSN: | 1932-8451 |
| DOI: | 10.1002/dneu.22403 |
| Popis: | Oxytocin (OXT) signaling through the OXT receptor plays a significant role in a variety of physiological processes throughout the lifespan. OXT's effects depend on the tissue distribution of the receptor. This tissue specificity is dynamic and changes across development, and also varies with sex, experience, and species. The purpose of this review is to highlight these themes with examples from several life stages and several species. Important knowledge gaps will also be emphasized. Understanding the effective sites of action for OXT via its receptor will help refine hypotheses about the roles of this important neuropeptide in the experience-dependent development and expression of species-typical social behavior. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 143-157, 2017. |
| Databáze: | OpenAIRE |
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