Correlation of Vascular Endothelial Growth Factor Expression and Neovascularization with Colorectal Carcinoma: A Pilot Study
| Autor: | Hala Abdel Dayem Mohamed, Wagdy Talaat Yossef, Makram Mohamed Hammam, Howyada Sayed Abd El All, Amr Abd El Aziz Kamel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis business.industry Colorectal cancer Perineural invasion medicine.disease digestive system diseases Metastasis Neovascularization Vascular endothelial growth factor chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Immunohistochemistry medicine.symptom business Lymph node |
| Zdroj: | Journal of Adenocarcinoma. |
| ISSN: | 2572-309X |
| DOI: | 10.21767/2572-309x.100005 |
| Popis: | Background: In Egypt, there is an increasing incidence of colorectal cancer (CRC), especially among patients under 40 years of age, affecting a very important age group in our community. The basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor induced angiogenesis. The aim of this study was to evaluate the angiogenesis in colorectal carcinoma by detect the expression of VEGF vascular endothelial growth factor and micro vascular density (MVD) determination with IHC (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. Methods and findings: Sixty five archival, paraffin embedded tissue samples of colorectal carcinoma from Pathology Lab of Suez Canal University Teaching Hospital (Egypt) with complete follow-up files in Oncology Unit from. VEGF and micro vessels were identified immunohistochemically, using monoclonal VEGF antibody and CD34 antibody, respectively. VEGF IHC expression was positive in 94.7% of cases and MVD ranged from 9 to 42 mean 24.55 ± 13.79. A significant positive relation was found between VEGF expression; and histological type, tumor grade, lymph node (LN) involvement, UICC TNM classification, perineural and lympho-vascular invasions (p |
| Databáze: | OpenAIRE |
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