FLUID-PERCUSSION BRAIN INJURY ADVERSELY AFFECTS CONTROL OF VASCULAR TONE DURING HEMORRHAGIC SHOCK
| Autor: | David A. Hovda, M M Law, H G Cryer |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Mean arterial pressure
medicine.medical_specialty Resuscitation business.industry Hemodynamics Vasodilation Blood flow Critical Care and Intensive Care Medicine Coronary circulation medicine.anatomical_structure Blood pressure Shock (circulatory) Internal medicine Emergency Medicine medicine Cardiology medicine.symptom business |
| Zdroj: | Shock. 6:213-217 |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/00024382-199609000-00010 |
| Popis: | To test the hypothesis that brain injury impairs control of vascular tone during compensation from hemorrhagic shock, Sprague-Dawley rats underwent fluid-percussion brain injury (or sham injury control) followed by a stepwise hemorrhage period to 1/2 baseline mean arterial pressure (1/2 MAP), a shock period holding at 1/2 MAP for 30 min, and a resuscitation period. Aortic blood flow (ABF) was measured and vascular conductance (ABF/MAP) was calculated. No differences occurred between groups during the stepwise hemorrhage period. During the 30 min shock period, controls decreased conductance from .2 +/- .07 to .16 +/- .04 and required repeated additional hemorrhage (3.4 +/- 1.3 cc) to maintain 1/2 MAP. In contrast, brain-injured animals increased conductance from .21 +/- .07 to .24 +/- .06 (p < .05) during the shock period and required repeated fluid replacements (3.0 +/- 1.3 cc lactated Ringer's (LR), p < .05) to maintain 1/2 MAP. Following resuscitation, conductance appropriately increased to .31 +/- .05 in controls but did not change (.25 +/- .04, p < .05) in brain-injured animals. We conclude that brain injury adversely affects control of vascular tone during shock and resuscitation in this model. |
| Databáze: | OpenAIRE |
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