Stenosis Assessment via Volumetric Flow Rate Calculation
| Autor: | Andrey Svitenkov, Oleg A. Shramko, Pavel Zun |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Computational Science – ICCS 2021 ISBN: 9783030779665 ICCS (3) |
| Popis: | Coronary artery stenosis is a condition that restricts blood flow to the myocardium, potentially leading to ischemia and acute coronary events. To decide whether an intervention is needed, different criteria can be used, e.g. calculation of fractional flow reserve (FFR). FFR can also be computed based on computer simulations of blood flow (virtual FFR, vFFR). Here we propose an alternative, more direct, metric for assessing the hemodynamic value of stenosis from computational models, the computed volumetric flow drop (VFD). VFD and vFFR are computed for several stenosis locations using a 1D model of the left coronary tree, and also an analytical model is presented to show why FFR value may differ from the true flow reduction. The results show that FFR = 0.8, which is often used as a criterion for stenting, may correspond to a reduction in volumetric flow from less than 10% to almost 30% depending on the stenosis location. The implications are that FFR-based assessment may overestimate the hemodynamic value of stenosis, and it’s preferable to use a more direct metric for simulation-based estimation of stenosis value. |
| Databáze: | OpenAIRE |
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