| Autor: |
Rani Cs, Deery W, James B. Field, Taguchi M, Ribeiro-Neto F, Pasquali D |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781475720600 |
| DOI: |
10.1007/978-1-4757-2058-7_10 |
| Popis: |
Although most of the metabolic effects of TSH on the thyroid reflect its activation of the adenylate cyclase-cAMP system (1), other signalling systems mediate the effect of other agonists such as acetylcholine (2) and phorbol esters (3). Furthermore effects of TSH on desensitization (4) and 32P incorportation into phospholipids (1) are not mediated by cAMP. The phosphatidylinositol 4,5-bisphosphate cascade which increases intracellular Ca2+ and activates protein kinase C is present in the thyroid and may be important for the regulation of several metabolic effects (5–9). ADP ribosylation of various proteins is another possible signalling system for cell regulation (10–13). Although this process may involve either poly ADP ribosylation or mono ADP ribosylation, the present discussion will be limited to the latter process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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