Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD
| Autor: | Maureen Carlyle, Jonathan Kurlander, Charlie Strange, Michael DePietro, Lauren A. Millette, Junliang Tong, Valery Walker, Eric Wittbrodt |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
COPD
medicine.medical_specialty Activities of daily living biology medicine.drug_class business.industry Fixed-dose combination General Medicine Lama medicine.disease biology.organism_classification 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Bronchodilator Internal medicine Cohort Propensity score matching medicine 030212 general & internal medicine business Asthma |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease. 14:1377-1388 |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s194856 |
| Popis: | Background: This study compared real-world patient-reported outcomes (PROs) measured by the Clinical COPD Questionnaire (CCQ), the London Chest Activities of Daily Living (LCADL) scale, and the Work Productivity and Activity Impairment (WPAI) questionnaire between individuals with COPD initiating LAMA/LABA fixed-dose combination (FDC) dual therapy versus either long-acting muscarinic antagonist (LAMA) or long-acting beta2-agonist (LABA) monotherapy. Methods: Individuals with COPD aged ≥40 years initiating a LAMA/LABA FDC dual therapy or a LAMA or LABA monotherapy (index date = first prescription date) between January 1, 2016 and December 31, 2016 were identified from a large US administrative claims database. Individuals were excluded if they were prescribed an inhaled corticosteroid (ICS) or ICS/LABA two months prior to the index date or were diagnosed with cystic fibrosis, idiopathic pulmonary fibrosis, or asthma. The cohorts were propensity score matched (PSM) 1:1 for COPD severity using baseline measures. Each participant completed a survey. Results: Surveys were completed by 399 participants in the dual therapy cohort, and 718 participants in the monotherapy cohort. Following PSM, 379 participants remained in each cohort for analysis (monotherapy: 369 LAMA and 10 LABA). The dual therapy cohort reported fewer COPD-related symptoms (CCQ symptom score 2.75 vs 2.97, respectively, P=0.023), and, fewer limitations in leisure activities (LCADL leisure score 4.78 vs 5.17, respectively, P=0.021) versus the monotherapy cohort. No significant differences were found in the WPAI. A greater percentage of participants in the dual therapy cohort stayed on index therapy (63.1%) when compared with the monotherapy cohort (30.3%, P |
| Databáze: | OpenAIRE |
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