The protective effect of magnesium on acute catecholamine cardiotoxicity in the neonate
| Autor: | Janet M. Augustine, Lee N. Benson, Joseph Caspi, Stanley L Herman, Arnost Kolin, Gregory J. Wilson, Anna Brezina, John G. Coles, Roberto J. Diaz |
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| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
Calcium metabolism medicine.medical_specialty Cardiotoxicity Ventricular function Magnesium business.industry chemistry.chemical_element Plasma levels Group B Epinephrine Endocrinology chemistry Internal medicine medicine Catecholamine Surgery Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 105:525-531 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)34236-9 |
| Popis: | Neonates undergoing heart surgery are exposed to high levels of circulating catecholamines. Our objective was to determine to what extent administration of magnesium counters epinephrine-induced cardiotoxicity. We assessed left ventricular function (pressure-volume data obtained by the conductance catheter/micromanometer technique) and ultrastructure in newborn pigs 3 to 5 days of age before and after administration of epinephrine alone (2 μg/kg/min, group A, n = 6) and simultaneously with magnesium sulfate (8 mmol/L, 5 ml/hr, group B, n = 6). Plasma levels of magnesium were maintained at 200 % to 250% of control, and ionized calcium was maintained at normal levels. During administration of epinephrine, there was a significant increase in end-systolic elastance from 8.9 ± 2 to 15 ± 3 mm Hg/ml in group A and from 7.8 ± 2 to 16 ± 3 mm Hg/ml in group B (p |
| Databáze: | OpenAIRE |
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