Systemic responses of preterm newborns with presumed or documented bacteraemia
| Autor: | Francis J. Bednarek, T. Michael O'Shea, Elizabeth N. Allred, Olaf Dammann, Raina N. Fichorova, Alan Leviton |
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| Rok vydání: | 2011 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pediatrics business.industry Acute-phase protein Gestational age pathological conditions signs and symptoms General Medicine Bowel perforation bacterial infections and mycoses medicine.disease Gastroenterology Blood proteins Infant newborn hemic and lymphatic diseases Internal medicine Bacteremia Pediatrics Perinatology and Child Health Necrotizing enterocolitis medicine Gestation business |
| Zdroj: | Acta Paediatrica. 101:355-359 |
| ISSN: | 0803-5253 |
| Popis: | Aim: To compare the frequency of elevated concentrations of inflammation-related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic-treated but culture-negative) bacteraemia to those who had neither. Methods: The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample. Results: Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation-related proteins, while those who had presumed late (weeks 2–4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia had a moderately strong signal, while those who had documented late bacteraemia had a stronger signal with more protein concentrations elevated on two separate occasions a week apart. Conclusions: Culture-confirmed early and late bacteraemia are accompanied/followed by systemic inflammatory responses not seen with presumed early and late bacteraemia. |
| Databáze: | OpenAIRE |
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