| Autor: |
Karunakar Hegde, Shilpa Shetty, Ms. Pratheeksha |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical Sciences Review and Research. :33-40 |
| ISSN: |
0976-044X |
| DOI: |
10.47583/ijpsrr.2022.v74i01.006 |
| Popis: |
The apple cider vinegar (ACV) was evaluated for its antiurolithiatic activity in experimentally induced urolithiatic rats. Urolithiasis was induced by administration of sodium oxalate (70mg/kg) intraperitonially to adult male Wistar albino rats (150-200g) for seven days served as a preventive regimen and ethylene glycol (0.75% v/v) in drinking water for 28 days served as a curative regimen. Two doses ACV (0.51ml/kg) and ACV (1.02 ml/kg) were subjected for the evaluation of antiurolithiatic activity. Cystone (750mg/kg) was served as standard in both the models. It was observed that experimentally induced Urolithiasis in both the conventional model elevated calcium, oxalate, uric acid concentration in urine also serum creatinine and uric acid levels were elevated. Similarly, reduction in magnesium levels was seen. Treatment with ACV (0.51ml/kg) and ACV (1.02ml/kg) significantly restored all elevated Urine and serum biochemical parameters in both prophylactic and curative regimen. Kidney homogenate analysis and assessment of physical parameters confirmed the antiurolithiatic effects of ACV. Histopathological findings also showed improvement in kidney architecture after treatment with ACV. The present study concluded that apple cider vinegar was found to be effective against Urolithiasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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