Drug release controlled by plasma-irradiation
| Autor: | Masayuki Kuzuya, Yoko Matsuno |
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| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Drug Delivery System. 8:149-159 |
| ISSN: | 1881-2732 0913-5006 |
| DOI: | 10.2745/dds.8.149 |
| Popis: | Controlled-release tablet can be obtained by oxygen plasma irradiation(radio-frequency discharges operating at 13.56 MHz) on the outermost layer of the double-compressed tablet which was fabricated from theophylline as a core material and a mixture of plasma-degradable polyoxymethylene (POM) and plasma-cross-linkable polystyrene (PST) as a wall material. Insulin controlled-release tablet can be obtained similarly by use of a mixture of POM and polylactic acid (PLA) as a wall material. Polycarbonate (PC) derived from bisphenol A can be considered to be of intramolecular bifunctionality, crosslinkable and degradable, as a plasma irradiation effect. Thus, theophylline controlled-release tablet can also be obtained by use of PC as a single wall material of the double-compressed tablet. The dissolution profiles are capable of being varied so as to cause release of drugs at different rates, depending on the set of conditions chosen for tablet fabrication as well as plasma operational conditions. SEM observation of the tablet surface clearly indicated that the theophylline has been released from the tablet through the resulting micropores. There are several obvious advantages of the present approach over other methods for fabrication of DDS device : The first is the avoidance of direct plasma-exposure to the drug. The present method is totally dry process, which eliminates the need for any workup such is required in the method in conventional wet processes. Further, one of the characteristics of plasma irradiation is the fact that it is surface-limited so that it does not affect the bulk properties of the polymeric pharmaceutical aids. |
| Databáze: | OpenAIRE |
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