Octopamine receptors on limulus and periplaneta central neurons
| Autor: | Robert J. Walker, C.Jane Roberts |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
medicine.medical_specialty animal structures biology Immunology Depolarization Anatomy Hyperpolarization (biology) Cyproheptadine biology.organism_classification Phentolamine Endocrinology nervous system Internal medicine Limulus medicine Excitatory postsynaptic potential Intracellular Periplaneta medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 69:301-306 |
| ISSN: | 0306-4492 |
| DOI: | 10.1016/0306-4492(81)90142-8 |
| Popis: | 1. 1. Intracellular recordings were made from neurons in the mid-dorsal region of the abdominal ganglia of Periplaneta americana and from unidentified neurons in the abdominal ganglia of Limulus polyphemus . (±)-Octopamine hyperpolarized Periplaneta neurons and in some cases this hyperpolarization was followed by depolarization, that is, a biphasic response. (±)-Octopamine hyperpolarized Limulus neurons without an excitatory component. 2. 2. D (—)-Octopamine and L -(+)-octopamine are approximately equipotent on Periplaneta neurons, the (+)-isomer being 2.5 times less potent than the (—)-isomer. While on Limulus neurons, D (—)-octopamine is more than 100 times more potent than L (+)-octopamine. 3. 3. Both phentolamine and cyproheptadine, 2–3 × 10 −6 M, reversibly blocked the hyperpolarization component of the octopamine response on both Periplaneta and Limulus neurons. In the presence of cyproheptadine, the octopamine response of Periplaneta neurons is reversed to one of excitation. |
| Databáze: | OpenAIRE |
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