GLC Determination of Chlorpheniramine in Human Plasma Using a Nitrogen Sensitive Thermionic Detector

Autor:	William C. Bryant, James E. O'Brien, Floyd E. Leaders, Lewis P. Amsel, Hinsvark On
Rok vydání:	1977
Předmět:	Nitrogen–phosphorus detector Chromatography Biochemistry (medical) Clinical Biochemistry Detector Extraction (chemistry) Ether Plasma Biochemistry Analytical Chemistry Hexane chemistry.chemical_compound chemistry Electrochemistry Gas chromatography Selectivity Spectroscopy
Zdroj:	Analytical Letters. 10:1163-1173
ISSN:	1532-236X 0003-2719
DOI:	10.1080/00032717708067852
Popis:	A highly sensitive procedure for the determination of plasma levels of the antihistamine, chlorpheniramine (CPA) is presented. Following the administration of therapeutic doses (4–8 mg) of CPA, plasma levels of the drug can be expected to be low. To reliably and accurately measure such levels, an ultrasensitive means of determining the concentration is required. A preliminary extraction with ether, a back-wash into acid, a final basic extraction into hexane with subsequent measurement by a gas chromatograph equipped with a nitrogen sensitive detector, provides the required selectivity, sensitivity and speed of analysis. In an expenditure of less than 10 minutes, 1 ng of CPA per ml of plasma can be reliably determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cc9ad34a1dabb1497d2004e6054bc5bb https://doi.org/10.1080/00032717708067852 Zobrazit plný text záznamu