| Autor: |
Luis Ostrosky-Zeichner, Zekaver Odabasi, Jose R. Rodriguez, Gerhard J. Leitz, Victor L. Paetznick, Enuo Chen, John H. Rex |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Mycoses. 53:438-442 |
| ISSN: |
0933-7407 |
| Popis: |
Summary A ‘trailing’ effect has been commonly observed when azole antifungals are tested against Candida spp. Previous experience with fluconazole indicates that 24-h minimum inhibitory concentration (MIC) values are more compatible endpoints when compared with clinical outcomes. We evaluated the trailing effect of Candida isolates tested with itraconazole in a guinea pig model of systemic candidiasis. Survival and organ burden were only significantly affected by using a higher dose of itraconazole, irrespective of the MIC differences at 24 and 48 h. A fluconazole-resistant strain with susceptible dose-dependent MICs to itraconazole was successfully treated with high-dose itraconazole. Our data suggests that survival and microbiological response depend more on drug dosing than on the trailing phenotype of the isolates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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